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KMID : 0191120130280101555
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Journal of Korean Medical Science
2013 Volume.28 No. 10 p.1555 ~ p.1558
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RET Fusion Genes in Korean Non-Small Cell Lung Cancer
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Yoo Seung-Soo
Jin Guang
Jung Hye-Jin
Hong Mi-Jeong
Choi Jin-Eun
Jeon Hyo-Sung
Lee Shin-Yup
Lim Jeong-Ok
Park Jae-Yong
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Abstract
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Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three patients were females and never smokers with adenocarcinomas. RET fusion genes were mutually exclusive from EGFR, KRAS mutations and EML4-ALK fusion. RET fusion genes occur 1.9% (3 of 156) of surgically treated NSCLC patients in Koreans.
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KEYWORD
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RET Fusion, KIF5B, CCDC6, Carcinoma, Non-Small-Cell Lung, Korean
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